Predictive value of glycated hemoglobin in relation to cardiovascular diseases in non-diabetics
Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Cardiovascular diseases are a major cause of morbidity and mortality. Current knowledge suggests that there is a relationship between glycated hemoglobin (HbA1c) and cardiovascular diseases, also in non-diabetics. Glycated hemoglobin (HbA1c) is a laboratory indicator that reflects the average blood sugar level over the past two to three months. Statistical methods. We determined monitored parameter: glycated hemoglobin. We determined the mentioned disease states. We expressed the relationship as a ratio of chances (Odds ratio, OR) (Mikulecký, M. 2003). The results of our work showed that non-diabetics who have an HbA1c value of 5.45 and higher have an risk of coronary heart disease 2.171 times higher compared to non-diabetics who have an HbA1c lower than 5.45 (OR=2.171) (95 % IS 1.095 – 4.304), the influence of the presence of HbA1c on the occurrence of coronary heart disease is statistically significant in this case (p ≤ 0.05). In non-diabetics, we demonstrated the effect of HbA1c on the development of the disease even in the case of the risk of myocardial infarction, stroke, peripheral arterial disease of the lower limbs, the results were statistically non-significant. Further studies are needed to clarify the relationship between HbA1c and cardiovascular diseases in non-diabetics.
Source: Research Square
Authors: Želmíra Daňová, Attila Czirfusz
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225319399