Combined hyperproliferative disorders of the reproductive organs - from pathogenesis to effective therapy
Year: 2026
Type: article
Abstract: The 21st century created a number of insurmountable challenges for the global medical community. Unfortunately, comorbidity remains one of the main attributes of modern medicine in general and reproductive medicine in particular. An absolute majority of hyperproliferative gynecological disorders have common pathogenetic patterns that are based on the following: abnormal proliferation, abnormal inflammation, neoangiogenesis, and dysfunction of apoptosis. Adenomyosis and uterine fibroid are still among the commonly co-existing hyperproliferative disorders of the reproductive system significantly reducing the quality of life of women, regardless of the age. The review considers the key features of the adenomyosis and uterine fibroid pathogenesis, provides modern approaches to the medication-based management of adenomyosis and uterine fibroid in cases of the combination of these disorders in terms of modern domestic and international protocols. Keywords: uterine fibroid, endometriosis, adenomyosis, pathogenesis, gonadotropin-releasing hormone agonists, gonadotropin-releasing hormone antagonists, relugolix, norethisterone acetate, estradiol hemihydrate.
Authors: Mekan R Orazov, Evgeny D Dolgov
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7225322507