Year: 2026
Type: article
Abstract: Histiocytoid Sweet syndrome (H-SS) is a variant of Sweet syndrome characterized by a dermal infiltrate of immature myeloid cells with histiocytoid morphology rather than mature neutrophils. These cells express myeloid markers including myeloperoxidase, lysozyme, CD15, and CD13. H-SS has been associated with hematologic malignancies and demonstrates higher relapse rates compared with classic Sweet syndrome. This review synthesizes current evidence on the clinicopathologic features, immunophenotype, disease associations, and treatment of H-SS, and examines its position within the broader spectrum of myeloid cutaneous infiltrates.
Source: Journal of Cutaneous Pathology
DOI: 10.1111/cup.70233
Authors: Ava Scott, Emily Smith
Institutions: Saint Louis University, Saint Louis University Hospital
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7225333583