Year: 2026
Type: article
Abstract: Acute-on-chronic liver failure (ACLF) is an acute and critical condition among liver diseases with rapid progression, easy combination with multiple organ failures, poor prognosis, and high mortality. Currently, there is a lack of specific therapeutic agents. Therefore, early-stage warning has become a hot research topic. In recent years, new progress has been made in exploring the pathogenesis of chronic liver disease progression to ACLF, namely the systemic inflammation hypothesis and cirrhosis-related immune dysfunction. This paper summarizes the potential significance of early warning biomarkers based on relevant studies of their pathogenesis over the past five years, aiming to provide scientific evidence and new ideas for shifting "treatment" to "prevention" of ACLF in clinical practice.
Source: PubMed Central
Authors: Hu Rui, Zhang Liting, Li Junfeng
Institutions: Lanzhou University, First Hospital of Lanzhou University
Language: Chinese
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G7574270497, G8989272728
OpenAlex ID: W7225334332