Work

Mitral valve disease in rheumatic heart disease, systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid Arthritis

Year: 2026

Type: review

Abstract: Mitral valve disease occurs in rheumatic heart disease (RHD) and selected systemic autoimmune rheumatic diseases, but similar lesions may have different underlying mechanisms. This structured narrative review examines epidemiological, mechanistic, imaging, and management evidence, distinguishing established pathways from incompletely validated mechanisms and hypotheses. In RHD, post-streptococcal valvulitis leads to fibrotic remodeling, commissural fusion, and chordal shortening, producing mitral stenosis, regurgitation, or mixed disease. A meta-analysis of 215,552 children and adolescents in endemic settings reported echocardiographically detected RHD in 24 per 1000. In systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), typical findings include leaflet thickening, Libman-Sacks vegetations, and regurgitation; embolic complications may occur despite mild valve dysfunction. Among 508 clinically selected patients with SLE undergoing echocardiography, 27.4% had heart valve involvement and 11.2% had mitral involvement. Immunothrombotic mechanisms may contribute to these lesions, but direct validation in human valve tissue remains incomplete. In rheumatoid arthritis (RA), a prospective cohort found an association with incident mitral regurgitation (adjusted hazard ratio 1.54, 95% confidence interval 1.32-1.81), but not mitral stenosis. Myocardial imaging findings do not establish a causal link to regurgitation. These findings support anatomy- and severity-based assessment in RHD, combined valvular and thromboembolic evaluation in SLE/APS, and assessment of conventional regurgitation mechanisms in RA. The framework informs clinical interpretation within existing guidelines, while proposed disease-specific mechanisms require further validation.

Source: Rheumatology International

DOI: 10.1007/s00296-026-06345-4

Authors: Mateusz Lucki, Bogna Grygiel-Górniak, Ewa Lucka, Maciej Lesiak

Institution: Poznan University of Medical Sciences

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,990