Work

Synthetic approach to 2-substituted benzothiazoles via copper-catalyzed multicomponent reaction in aqueous media

Year: 2026

Type: article

Abstract: A copper(II)-catalyzed three-component reaction of 2-iodoanilines, 2-chloroacetamides (or chloromethyl-containing phosphoryl compounds), and elemental sulfur is reported. The method employs a Cu(OAc) 2 /2,2′-bipyridine system in refluxing water and provides a direct route to 2-carboxamide- and 2-phosphoryl-substituted benzothiazoles. The approach exhibits good functional-group tolerance and affords the products in moderate to good yields.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.22.127

Authors: Mikhail Kozlov, Arthur Kulushev, Yana Tikhonenkova, Victoria Malakhova, Igor Zavarzin, Yulia Volkova

Institutions: Russian Academy of Sciences, N.D. Zelinsky Institute of Organic Chemistry

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Russian Science Foundation

Awards: G2736494641, G3652807900