Establishment of Aspergillus fumigatus-specific IgG cut-off level for diagnosis of chronic pulmonary aspergillosis in the Iranian population.
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background and Purpose: IgG in CPA diagnosis and validate its diagnostic accuracy in the Iranian population. Materials and Methods: IgG was determined using the receiver operating characteristics (ROC) curve and Youden's index and was subsequently validated. Results: <0.001). Conclusion: IgG, with a cut-off value of 23.5 U, provided moderate sensitivity and specificity for screening and may be used in combination with the culture method to confirm the diagnosis of CPA in COPD patients. However, the variability in cut-off values across different populations highlights the need for standardized guidelines to improve diagnostic consistency and reliability.
Source: PubMed Central
Authors: Sabrieh Asadi Shahi Sarae, Masoud Aliyali, Vida Mortezaee, Hamidreza Jamaati, Hossein Asgarian Omran, Siavash Abedi, Hossein Mehravaran, Jamshid Yazdani Charati, Maryam Sadat Mirenayat, Mihan Pourabdollah, Somayeh Lookzadeh, Maryam Moazeni, Sabah Mayahi, Mona Ghazanfari, Iman Haghani, Mahdi Abastabar, Mohammad T Hedayati
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225343753