“Immune-Mediated Cerebellar Ataxia Secondary to Longstanding Seropositive Rheumatoid Arthritis - A Case Report”
Year: 2026
Type: article
Study design: Case Report
Abstract: Cerebellar dysfunction caused by autoimmune processes is the hallmark of immune-mediated cerebellar ataxia (IMCA), a rare neurological condition that is most frequently idiopathic or paraneoplastic. It is scarce and still poorly understood to be associated with rheumatoid arthritis (RA). We describe the case of a 58-year-old man with long-standing seropositive RA who had growing gait instability and imbalance for a week without focal neurological abnormalities or a flare-up of the systemic illness. Gait ataxia, poor tandem walking, and mild limb dysmetria were found during a neurological evaluation. A thorough examination revealed minor cerebellar cortical alterations, suggesting inflammatory involvement, despite the initial brain magnetic resonance imaging being classified as normal. Vascular, viral, metabolic, demyelinating, and drug-related causes were ruled out after a thorough investigation. Neuronal autoantibody testing and cerebrospinal fluid analysis were not possible due to patient refusal and resource limitations. Therefore, clinical presentation, elimination of other etiologies, imaging results, and a positive response to immunotherapy were used to establish the diagnosis of IMCA secondary to RA. After receiving high-dose intravenous corticosteroid therapy, the patient demonstrated significant clinical improvement and continued to recover at follow-up. Even in the absence of active systemic disease, this example underscores the importance of considering immune-mediated cerebellar ataxia when patients with systemic autoimmune disorders present with acute cerebellar symptoms.
DOI: 10.67464/h817t554
Institutions: Chittagong Medical College, Bahawal Victoria Hospital
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7225344133