Evaluation of the Anti-diabetic Activity of Ethanolic Extract of Thespesia Populnea in Streptozotocin Induced Diabetic in Rats.
Year: 2026
Type: article
Abstract: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, resulting from defects in insulin secretion, insulin action, or both. The present study was designed to evaluate the antidiabetic and antioxidant activity of the ethanolic extract of Thespesia populnea in streptozotocin (STZ)-induced diabetic rats.Diabetes was induced in Wistar albino rats by a single intraperitoneal injection of streptozotocin (50 mg/kg). Diabetic animals were treated with ethanolic extract of Thespesia populnea at two different doses (200 and 400 mg/kg, p.o.) for 21–28 days. Metformin (100 mg/kg, p.o.) was used as the standard drug. The antidiabetic activity was assessed by evaluating fasting blood glucose, oral glucose tolerance test, serum insulin level, and lipid profile parameters. In vitro antioxidant activity was determined using superoxide, nitric oxide, hydrogen peroxide, hydroxyl radical, and DPPH scavenging assays.The results revealed that the ethanolic extract significantly reduced fasting blood glucose levels, improved glucose tolerance, and increased serum insulin levels in a dose-dependent manner. The extract also improved lipid profile parameters by reducing total cholesterol, triglycerides, LDL, and VLDL levels while increasing HDL levels. Furthermore, the extract exhibited strong antioxidant activity against various free radicals in a dose-dependent manner, indicating potent free radical scavenging potential.The observed pharmacological effects may be attributed to the presence of bioactive phytoconstituents such as flavonoids, phenolic compounds, tannins, and terpenoids. The findings suggest that the ethanolic extract of Thespesia populnea possesses significant antidiabetic and antioxidant properties and may serve as a potential natural therapeutic agent for the management of diabetes mellitus and its associated complications. Further studies are required to isolate the active compounds and elucidate the exact mechanism of action.
Authors: V. Divya Rani, I. Veena Rani
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225346856