Safety Profile of a Magnetic Iron Oxide Nanoparticle-Based Device for Lens Removal: A Comparative Study with Phacoemulsification in a Rabbit Model
Year: 2026
Type: preprint
Abstract: Background To evaluate the ocular safety of a novel magnetic iron oxide nanoparticle-based device for lens removal compared to standard phacoemulsification. Methods Twelve New Zealand white rabbits were randomly assigned to either a novel device group or a phacoemulsification group with one rabbit from each group is excluded from the study. (n = S in each group), Only one eye from each rabbit was used. Scotopic and photopic electroretinogram (ERG) a-wave and b-wave amplitudes were recorded preoperatively and 4 weeks postoperatively. Corneal endothelial cell density was measured preoperatively and at 2 and 4 weeks postoperatively. Intraocular pressure (IOP) was measured preoperatively and at 1, 2, and 4 weeks postoperatively. After four weeks, the eyes were enucleated for Haematoxylin and Eosin (H & E) and Prussian blue staining of the cornea, iridocorneal angle, and sensory
Source: Research Square
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225390957