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Progression‐Associated Loss of SMARCB1/INI1 Expression in Mismatch Repair‐Deficient Glioblastoma

Year: 2026

Type: article

Abstract: A mismatch repair-deficient glioblastoma acquired a second SMARCB1 mutation with complete loss of SMARCB1 protein expression at recurrence. Acquired SMARCB1 deficiency may represent a progression-associated event in mismatch repair-deficient glioblastoma and constitute a diagnostic pitfall.

Source: Neuropathology and Applied Neurobiology

DOI: 10.1111/nan.70105

Authors: Enrico Küllenberg, Nils Warneke, Markus Holling, Abigail K. Suwala, Christian Thomas, Martin Hasselblatt

Institutions: University Hospital Münster, Heidelberg University, University Hospital Heidelberg

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,480