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Extracellular Vesicle mRNA Profiling for Prognostic Biomarker Discovery in Pediatric Osteosarcoma: the KIDsCAN Study

Year: 2026
Type: article
Abstract: Introduction: Osteosarcoma is a pediatric bone cancer with a guarded prognosis. Those that survive suffer from substantial long-term morbidity. Identification of prognostic biomarkers could guide therapy intensity to minimize long-term morbidity without compromising survival. KIDsCAN is a study identifying prognostic extracellular vesicle (EV) mRNA signatures in pediatric osteosarcoma.
DOI: 10.1016/j.jlb.2026.100552
Authors: Kelly Makielski, Jaron Magstadt, Jonah Cullen, Julia Miller, Adam Cook, Aaron Rendahl, Ali Khammanivong, Brenda Weigel, Logan Spector, Jaime Modiano
Language: English
Open Access status: gold
Estimated APC paid: $2,080
OpenAlex ID: W7225396303
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