Work

Encoding stability and dynamics in hydrogen-bonded octameric capsules through amino acid α-position design

Year: 2026

Type: article

Abstract: -symmetric octameric capsules. Substitution of the α-hydrogen with a methyl group disrupts solubility and capsular stability; however, introduction of long aliphatic side chains partially restores capsule formation, albeit with increased dynamics. Moreover, α-methylation profoundly affects capsule function, leading to a complete loss of fullerene encapsulation ability compared to the corresponding α-H-containing capsules. Overall, these results reveal how subtle variations at the α-position translate into emergent differences in stability, dynamics, function and architecture of hydrogen-bonded supramolecular capsules.

Source: Organic Chemistry Frontiers

DOI: 10.1039/d6qo01259k

Authors: Filip Perlitius, Grzegorz Markiewicz, Mateusz Gołdyn, Gokay Avci, Kim E. Jelfs, Artur R. Stefankiewicz

Institutions: Adam Mickiewicz University in Poznań, University College London, Imperial College London

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Narodowe Centrum Nauki, Engineering and Physical Sciences Research Council

OpenAlex ID: W7225400998