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A Rare Case of Recurrent Spontaneous Soft Tissue Hematomas in Chronic Myeloid Leukemia (CML) – Case Report

Year: 2026

Type: article

Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the Philadelphia chromosome, BCR–ABL1 fusion gene. Although bleeding manifestations are recognized, spontaneous soft-tissue hematomas are rare. We report a 21-year-old male with chronic-phase CML who developed recurrent spontaneous intramuscular hematomas in the absence of trauma. He presented with hyperleukocytosis and a gluteal hematoma complicated by compartment syndrome requiring surgical decompression. In the absence of identifiable coagulation abnormalities, a multifactorial mechanism, including hyperleukocytosis-associated microvascular dysfunction and possible qualitative platelet abnormalities, may have contributed. This case highlights an uncommon but serious complication of uncontrolled CML.

Source: SN Comprehensive Clinical Medicine

DOI: 10.1007/s42399-026-02548-9

Authors: Amit Keith Correa, Lily Chen, Amitesh Krishna Srinivasan, Monitha Pinnamaneni, Hardik Zinzala, Hila Shaim

Institution: Lyndon Baines Johnson Hospital

Language: English

Topic: Case Reports on Hematomas

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,090