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Diffuse Large B‐Cell Lymphoma Presenting as a Rapidly Enlarging Forehead Mass Initially Suggestive of a Subgaleal Hematoma: A Case Report

Year: 2026

Type: article

Abstract: ABSTRACT While diffuse large B‐cell lymphoma (DLBCL) occurring in the subcutaneous soft tissue is extremely rare, we present herein a case of DLBCL occurring in the forehead. A 70‐year‐old woman presented to the plastic and reconstructive department with a painless forehead mass. Although magnetic resonance imaging (MRI) initially suggested a subgaleal hematoma, subsequent computed tomography (CT) revealed bone destruction. Due to the progressive enlargement, a biopsy was performed, confirming a pathological diagnosis of DLBCL. A genetic analysis of tissue samples revealed MYC and BCL6 rearrangements consistent with double‐hit lymphoma (DHL). The patient was treated with the help of R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) followed by DA‐R‐EPOCH (dose‐adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin). Although the frontal skull mass completely resolved, residual disease persisted in the femur, ultimately leading to the patient's death. This case highlights the importance of including lymphoma in the differential diagnosis of rapidly enlarging soft tissue masses as well as the utility of early biopsy in ensuring timely intervention.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.73850

Authors: Akitomo Yonenaga, Nobuo Isono, Ami Higashiyama, Masao Tsukada, Keijiro Hori

Institutions: Tokyo Women's Medical University Adachi Medical Center, Tokyo Metropolitan Tama Medical Center

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820