Work

Performance Evaluation and Validation of a Next-Generation Sequencing-Based Measurable Residual Disease Assay for FLT3 Internal Tandem Duplication Detection in Acute Myeloid Leukemia

Year: 2026

Type: article

Abstract: Background: -ITDs) in measurable residual disease (MRD) remains challenging due to structural heterogeneity and the limited sensitivity of conventional methods. Methods: -ITDs in AML. Results: -ITD clones identified in 35.0% of patients and frequent detection of low-level microclones. Longitudinal analysis further revealed diverse clonal dynamics. Conclusions: -ITDs and enables high-resolution assessment of clonal dynamics, supporting its clinical utility for MRD monitoring in AML.

Source: Annals of Laboratory Medicine

DOI: 10.3343/alm.2026.0252

Authors: Jong-Mi Lee, Byung Sik Cho, Hee-Je Kim, Bit Na Kwon, Sungkyu Kyung, Ji Yeon Kim, Myungshin Kim, Yonggoo Kim

Institutions: The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7225419582

FWCI:

Cites:

Cited by:

Related to: 10