Work

Suramin inspires next-generation broad-spectrum antiviral design targeting RdRps

Year: 2026

Type: article

Abstract: Structural studies of diverse viral RNA-dependent RNA polymerases reveal that the broad-spectrum antiviral Suramin binds distinct sites while repeatedly exploiting conserved RNA-interacting and electrostatic features. This Pearl highlights common vulnerabilities within viral RNA polymerases and discusses how structural studies provide a framework for future antiviral design.

Source: PLoS Pathogens

DOI: 10.1371/journal.ppat.1014766

Authors: Arwen Baer, Ge Yang, Fan Bu, Bin Liu

Institutions: University of Minnesota, Gustavus Adolphus College

Language: English

Topic: Enzyme Structure and Function

Subfield: Structural Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,043