Work

Synthesis of Morpholine-containing 6h-1,3,4-thiadiazines Based on Α-bromohydroxyketones

Year: 2026

Type: article

Abstract: The article investigates the synthesis and formation mechanism of morpholine-containing 1,3,4-thiadiazine heterocycles. The reactions of α-bromo-3-methyl-3-hydroxybutan-2-one and α-bromo-3-methyl-3-hydroxypentan-2-one with morpholine-4-carbothiohydrazide are analyzed, with particular attention to the effects of tautomeric equilibrium, solvent, and alkaline conditions on the reaction pathway. The structures of the obtained compounds were confirmed by ¹H NMR and IR spectroscopy.

Source: Journal of Chemistry of Goods and Traditional Medicine

DOI: 10.55475/jcgtm/vol5.iss4.2026.711

Authors: Elmurod X. Pulatov, Toxir X. Abdullayev, Muzaffar J. Isobayev, Boronkul G. Mavlonov, Nushervon Hayotov

Institutions: Academy of Sciences of the Republic of Tajikistan, Institute of Chemistry named after V.I. Nikitin

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

OpenAlex ID: W7225422841

FWCI:

Cites: 1

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Related to: 10