Pharmacist Guide to Psilocybin and Psychedelic-Assisted Psychotherapy
Year: 2026
Type: article
Abstract: PURPOSE: This primer is designed to provide a broad overview of psilocybin and its use in medically supervised settings as part of psychedelic-assisted psychotherapy. This article will act as a framework to give practicing pharmacists the knowledge they need regarding pharmacology, pharmacokinetics, contraindications, adverse effects, and drug interactions that would impact safe use of psilocybin in medical settings. SUMMARY: Psychedelic-assisted psychotherapy has re-emerged in the last twenty years as a potential pathway to address a variety of mental health disorders. Interest in psilocybin has experienced a renaissance, and there have been pushes at federal, state, and local levels to expand access to this agent in research settings and within psychotherapy offices. While generally considered a very safe therapy, psilocybin does have several contraindications and clinically relevant drug-drug interactions that need to be considered when evaluating patient candidacy for psilocybin-assisted psychotherapy. CONCLUSION: Pharmacists play an important role in ensuring safe and effective use of psilocybin as it becomes more readily available and utilized across the globe. Recognition of relevant contraindications and drug-drug interactions is particularly essential to this process.
DOI: 10.1093/ajhp/zxag388
Institutions: University of Wyoming, Exempla Saint Joseph Hospital
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $4,448
OpenAlex ID: W7225427439
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