Host–pathogen interactions in severe odontogenic infection: linking abscess findings to anatomical spread
Year: 2026
Type: article
Abstract: Why do some odontogenic infections remain confined to one anatomical space while others extend into the deep neck? Recent studies have identified severity-associated microbial communities in maxillofacial abscesses, but organisms detected after infection has spread may reflect the established abscess environment as well as processes contributing to its development. Experimental studies demonstrate that selected oral bacterial combinations can enhance abscess formation and impair neutrophil antimicrobial activity, while human studies have identified inflammatory responses at infected sites. Whether these interactions contribute to specific patterns of anatomical spread remains unresolved. We propose that mechanistic investigation should connect microbial activity and local host responses with anatomically defined clinical manifestations, accounting for the dental source, host susceptibility, and treatment before sampling. Surgical drainage offers an opportunity to obtain anatomically characterized specimens and follow subsequent biological changes, although concurrent treatment limits causal attribution. Pairing local microbial and host measurements with targeted functional experiments could help distinguish pathogenic interactions from microbial adaptation to an established abscess. This approach may clarify the biology of severe odontogenic infection and identify findings that warrant independent evaluation for clinical relevance.
Authors: Zhaogao Zhang, Ziqi Yang, Yihao Pei
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7225429464