Mutational and phenotypic landscape of circulating vaccine‐derived Poliovirus 2 in sewage in a high vaccine coverage area
Year: 2026
Type: article
Abstract: The final phases of the Global Polio Eradication Initiative are challenged by the circulation of vaccine-derived polioviruses, particularly serotype 2, occurring even in certified polio-free countries. Integrated environmental surveillance and long-read deep sequencing enable resolution of the viral haplotype network. Structural modelling of this network reveals the poliovirus phenotypic landscape. Together, these approaches uncover the complete poliovirus quasispecies in a population of approximately 1.8 million inhabitants.
Source: iMetaOmics.
DOI: 10.1002/imo2.70153
Institutions: Universitat de Barcelona, Instituto de Salud Carlos III, Agència de Salut Pública de Catalunya, Hospital La Paz Institute for Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Centers for Disease Control and Prevention, Medicines and Healthcare products Regulatory Agency
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7225449182