Immunotherapy Clonal Dynamics Cohort Generator
Year: 2026
Type: article
Abstract: What this is Free demo of the Immunotherapy Clonal Dynamics Cohort Generator — a command-line tool producing fully synthetic cohorts of tumor clonal dynamics under immune checkpoint inhibition (nivolumab, pembrolizumab, atezolizumab). The model Five coupled ODEs drive every patient trajectory: Sensitive clone : dV_sens/dt = λ_s·V_sens·(1 − V_total/K) − α·I_eff·V_sens − κ·C_c·V_sens Resistant clone : dV_res/dt = λ_r·V_res·(1 − V_total/K) − α_r·I_eff·V_res (α_r < α, no drug kill) Effector immune population : dI_eff/dt = σ − δ·I_eff + (ρ0 + β·C_c)·I_eff·V_total/(V_total + K_half) Two-compartment PK : IV bolus, time-dependent clearance CL(t) = CL·(1 − emax·t^hill/(T50^hill + t^hill)) Three counterfactual treatment arms per patient: continuous (label dosing, 120 d), adaptive stop/resume (oracle controller), early aggressive (2× dose). Fixed-step RK4, 0.5-day output grid. Demo limitations 100 patients per run (full version: 10,000+). Fixed master seed 20260828. Frozen calibration. DEMO-stamped outputs. HMAC-signed license file. Output tables patients.parquet, treatment_regimens.parquet, clonal_profiles.parquet, outcomes.parquet — same schema as the full version. Validation Calibration anchors: melanoma ORR 0.376 vs 0.365, NSCLC 0.169 vs 0.172, renal 0.214 vs 0.215. 31/31 cohort checks PASS, 12/12 model unit tests PASS. 72 constants: 34 VERIFIED, 38 ESTIMATE_SOURCED, 0 ... Full description with all tables is on the Wiki page of this project. Full dataset and purchase: https://sentineldata.com.ua/dataset/immunotherapy-clonal-dynamics-cohort-generator . Zenodo copy: https://doi.org/10.5281/zenodo.23266706
Source: Open Science Framework
Author: Maksym Chekerskyi
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225451858