In Silico Replication and Stoichiometric Sweet Spot Optimization of the Curcumin-Piperine Synergy: Validating The Hygieia Platform v2.1 Against Landmark Human Pharmacokinetic Trials
Year: 2026
Type: article
Abstract: Deterministic in silico replication of the landmark human clinical trial by Shoba et al. (1998) evaluating curcumin bioavailability enhancement by piperine under ASME V&V 40 verification. In an adult European male reference physiology (73 kg), co-administration of 20 mg piperine with 2,000 mg curcumin increased free plasma Cmax by 26.1-fold (+2,510%), replicating the clinical 20-fold enhancement. Algorithmic Stoichiometric Sweet Spot exploration demonstrates that Shoba's 2,000 mg dose is an excessive megadose: the global Chou-Talalay synergistic optimum occurs at 1,000 mg Curcumin + 20 mg Piperine (CI = 0.178, Peak Synergism), achieving DRI = 2.00, conserving 365 g of active curcumin annually per patient while relieving hepatic Phase II glucuronidation saturation.
Author: Lanzett, Harri
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225453486