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Adsorption-controlled electrooxidation of ensartinib at a nanostructured Al2O3–MWCNT electrode: first electrochemical insights

Year: 2026

Type: article

Abstract: The electrochemical behavior of the recently approved anticancer drug ensartinib (ENS) was investigated for the first time at a carbon paste electrode incorporating Al 2 O 3 –MWCNT nanostructures. A distinct anodic signal was observed, with the voltammetric response indicating an irreversible oxidation event. Variation of the scan rate produced a proportional increase in peak current, supporting adsorption as the predominant process controlling the electrode reaction. Changes in solution pH were accompanied by systematic displacement of the oxidation potential, suggesting involvement of proton transfer during electron oxidation. Modification of the carbon paste surface with the Al 2 O 3 –MWCNT nanostructure increased the measured ENS response, which was attributed to enhanced interfacial adsorption and more efficient electron-transfer kinetics. These electrochemical characteristics were subsequently used to develop a differential pulse voltammetric procedure for ENS quantification at micromolar concentration levels. The method showed satisfactory analytical performance when applied to pharmaceutical formulations and spiked plasma samples. The findings establish the electrochemical oxidation characteristics of ENS at the modified electrode and demonstrate its suitability as the basis for voltammetric determination in the investigated matrices.

Source: BMC Chemistry

DOI: 10.1186/s13065-026-01945-4

Authors: Aisha A. Alsfouk, Lateefa A. Al-Khateeb, Omkulthom Al kamaly, Mahmoud A. Tantawy, Moayad M. Khashoqji, Aalaa E. Elkhamisy