Analysis code for a two-sample and two-step Mendelian randomization study of iron status, glycaemic traits and periodontitis
Year: 2026
Type: preprint
Abstract: Analysis code and documentation for a two-sample and two-step Mendelian randomization study examining whether type 2 diabetes and glycaemic traits mediate the causal effect of iron status on periodontitis. The archive contains 54 scripts (48 Python, 6 R) organised by analysis stage, covering data acquisition, clumping, harmonisation, Steiger filtering, univariable and multivariable estimation, two-step mediation and power calculations. Input data are publicly available from the consortia listed in DATA_SOURCES.md and are not redistributed here. The study was preregistered on OSF (DOI 10.17605/OSF.IO/QPXYH); this project archives the code only.
Source: OSF Preprints (OSF Preprints)
Author: Ying Yuan
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225465409