Synthesis of Sulfur-containing Organic Compounds Via Thiol–ene Click Chemistry
Year: 2026
Type: article
Abstract: This article discusses the theoretical foundations of thiol–ene and thiol–yne reactions within the framework of the click chemistry concept and their significance in the synthesis of sulfur-containing organic compounds. The photoinduced thiol–ene reaction between 1-hexene and 1-propanethiol for the synthesis of hexyl(propyl)sulfane is examined. The use of 2,2-dimethoxy-2-phenylacetophenone (DMPA) as a photoinitiator, ultraviolet irradiation at a wavelength of 365 nm, nitrogen purging of the reaction medium, and the effect of reaction time on process efficiency are discussed. The reaction mechanism is described in terms of thiyl radical formation, radical addition to the carbon–carbon double bond of the alkene, and subsequent hydrogen atom transfer leading to thioether formation. Furthermore, the importance of optimizing the photoinitiator concentration, irradiation intensity, and reactant molar ratio to improve product yield and selectivity is highlighted. This study provides a theoretical and practical basis for evaluating the potential of photoinduced thiol–ene reactions in the synthesis of sulfur-containing organic compounds.
Author: Erkinov Rasuljon
Institution: Namangan davlat texnika universiteti
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7225568385