Echocardiographic Markers of Left Ventricular Diastolic Dysfunction and Subclinical Myocardial Remodeling in Non-Diabetic Patients with Severe Insulin Resistance
Year: 2026
Type: article
Study design: Observational Study
Abstract: Systemic insulin resistance functions as a primary pathological catalyst for adverse myocardial remodeling, directly precipitating left ventricular diastolic dysfunction independent of overt hyperglycemia or obstructive coronary artery disease. The exact pathophysiological sequence translating metabolic dysregulation into structural cardiac decline remains poorly quantified in normoglycemic populations. This prospective longitudinal investigation aimed to evaluate the isolated impact of severe systemic hyperinsulinemia on subclinical myocardial mechanics, utilizing advanced tissue Doppler imaging and two-dimensional speckle-tracking echocardiography over a 24-month follow-up trajectory. A strictly selected cohort of 215 non-diabetic adult patients exhibiting varying degrees of metabolic syndrome was stratified based on baseline Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) quartiles. Serial echocardiographic analyses demonstrated a profound, dose-dependent deterioration in myocardial relaxation and compliance among highly insulin-resistant subjects. Patients in the highest HOMA-IR quartile (> 4.5) experienced an accelerated expansion of the Left Ventricular Mass Index from 92.4 ± 8.1 g/m2 at baseline to 118.6 ± 10.4 g/m2 at the final follow-up, alongside a critical elevation in the E/e' ratio reaching 14.2 ± 1.5, indicating severely elevated left ventricular filling pressures. Global longitudinal strain, a highly sensitive marker of early contractile failure, degraded significantly in the severe hyperinsulinemic group (-16.4 ± 1.2%) compared to the insulin-sensitive control cohort (-21.5 ± 0.9%). Multivariate regression confirmed fasting insulin levels as the strongest independent predictor of myocardial collagen deposition and diastolic stiffness, overriding the mechanical stress of concurrent prehypertension. Targeting the insulin-signaling cascade proactively at the pre-diabetic stage presents a vital therapeutic opportunity to arrest fibrotic myocardial remodeling and prevent the inevitable progression toward heart failure with preserved ejection fraction.
Author: Abdulhamidova Saydinsa
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225579161