Overexpression of Cytidine Triphosphate Synthetase 1 (CTPS1) and Deoxythymidylate Kinase (DTYMK) in Patients with Newly Diagnosed Esophageal Squamous Cell Carcinoma.
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: ). Emerging evidence highlighted the critical role of these enzymes in cancer progression. Methods: This cross-sectional study was conducted at Golestan University of Medical Sciences (Gorgan, Iran) in 2023. Initially, the Gene Expression database of Normal and Tumor tissue (GENT2) and the OncoDB database were checked to investigate the expression of these genes in esophageal cancer (EC) tissues. Subsequently, 34 pairs of newly diagnosed esophageal squamous cell carcinoma (ESCC) tissues and matched adjacent healthy tissues were collected. Real-time PCR was performed to measure the expression of these genes in the collected tissues. Statistical analyses were performed using SPSS version 22 and GraphPad Prism version 8. The Mann-Whitney test and the Wilcoxon matched-pairs signed-rank test were used to compare gene expression. P<0.05 was considered statistically significant. Results: expression was significantly higher in females (3.73 and 1.505-11.313) than in males (0.81 and 0.213-1.624, P=0.007). Conclusion: were overexpressed in ESCC tissues compared with adjacent healthy tissue, which could provide valuable insights for the development of ESCC treatment strategies.
Source: PubMed
Institution: Golestan University of Medical Sciences
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225579920