The Circular Polar Model of Dr Mihăilă Graphic System®: Axiomatic Architecture, Causal Language, and Construction Methodology │ Illustrated Through Text-Based and Linear Model-Based Applications in Iron – Hepcidin Homeostasis, Erythropoiesis, and Adaptive Immune Response
Year: 2026
Type: article
Abstract: Causality and feedback processes exist independently of human observers. Scientific disciplines do not create these processes; rather, they discover, study, and describe them. Textual explanations, linear diagrams, mathematical formulations, and graphical models are therefore not the processes themselves but human-created expressions of those processes. The Circular Polar Model (CPM) should be viewed within this context. CPM does not propose new physiological mechanisms. Instead, it represents an alternative human-oriented expression of causal architectures already present in biological reality and previously described through textual and linear representations. Its purpose is to facilitate recognition of causal organization, shared routes, feedback structures, and hidden relationships through a geometry optimized for human pattern recognition. Future representations may certainly emerge, just as CPM emerged from a change in perspective applied to already established knowledge. Methodology Notice: All diagrams in this manuscript were created using the Dr Mihăilă Graphic System®, a standardized visual method for transforming causal relationships into intuitive geometric models (multi‑axis structures and circular‑arc feedback systems). This graphical methodology has been fully detailed in our foundational work and is applied here to the specific domain addressed in this manuscript. Trademark Notice: Dr Mihăilă Graphic System® is an officially registered trademark under the European Union Intellectual Property Office (EUIPO). Public registration record: EUIPO - eSearch Keywords Iron homeostasis, Hepcidin, Ferroportin, Erythropoiesis, Erythropoietin (EPO), Adaptive immune response, Negative feedback loops, Homeostatic regulation, Circular model, Dr Mihăilă Graphic System®, Didactic physiology, Systems biology, Conceptual modeling, Medical education, Pathophysiology, Feedback architecture, Loop failure, Pedagogical frameworks Note: This work is part of the Core Models in Physiology system, which has been downloaded over 9,700 times (and counting) by educators and students worldwide. The System's Foundation: · Built exclusively on established medical literature. · Designed as a complementary visual framework to traditional textbooks. Its Unique Power: · Provides a unified graphical language for causality and feedback. · Scalable and consistent across all physiological systems. · Proves its universal power by modeling diverse adaptive systems (from physiology to ecology) with the same core rules. Explore the full Core Models Collection New Core Models currently under construction. All titles listed below are developed exclusively under the Dr Mihăilă Graphic System® didactic framework. A Graphic System for Teaching Physiological Causality and Beyond. Rules and Core Model Collection https://doi.org/10.5281/zenodo.15476147 [Foundational Manuscript] This work is published under CC BY-NC-ND 4.0. license and discoverable also on: - OER Commons (A Graphic System for Teaching Physiological Causality and Beyond. Rules and Core Model Collection | OER Commons), - Share My Lesson (Robert Ioan Mihaila | Share My Lesson), and - MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital libraries as a curated and catalogued resource. - BASE BASE (Bielefeld Academic Search Engine): Hit List Core Endocrine Models I: A Graphic Causality System for Teaching Pancreatic and Adrenal Regulation https://doi.org/10.5281/zenodo.15352067 This work is published under CC BY-NC-ND 4.0. license and discoverable also on: - OER Commons (Core Endocrine Models I: A Graphic Causality System for Teaching Pancreatic and Adrenal Regulation | OER Commons), - Share My Lesson (Robert Ioan Mihaila | Share My Lesson), and - MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital libraries as a curated and catalogued resource. - BASE BASE (Bielefeld Academic Search Engine): Hit List Core Endocrine Models II: A Graphic Causality System for Hierarchical Axes, Multi-Loop Integration and Clinical Pattern Recognition https://doi.org/10.5281/zenodo.15698563 This work is published under “All rights reserved” and discoverable also on: - MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital library as a curated and catalogued resource. - BASE BASE (Bielefeld Academic Search Engine): Hit List Core Models in Gastrointestinal Physiology: A Graphic Causality System Approachhttps://doi.org/10.5281/zenodo.15831259 This work is published under CC BY-NC-ND 4.0. license and discoverable also on: - OER Commons (Core Models in Gastrointestinal Physiology: A Graphic Causality System Approach | OER Commons), - Share My Lesson (Robert Ioan Mihaila | Share My Lesson), and - MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital libraries as a curated and catalogued resource. - BASE BASE (Bielefeld Academic Search Engine): Hit List Pressure-Flow Modeling: A Unified Causal Framework for Cardiovascular and Renal Homeostasis. Core Models from Baroreceptor Reflex to Glomerular Hemodynamics https://doi.org/10.5281/zenodo.17143368 This work is published under “All rights reserved” and discoverable also on: - MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital library as a curated and catalogued resource. - BASE BASE (Bielefeld Academic Search Engine): Hit List Economic Homeostasis: A Universal Causal Framework for Stability, from Physiological to Economic Systems https://doi.org/10.5281/zenodo.17476317 This work is published under “All rights reserved” and discoverable also on: MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital library as a curated and catalogued resource. Core Models: One Code to Rule Them All! How the Same Loops Govern Your Body, Nature, and the Marketplace https://doi.org/10.5281/zenodo.17562888 This work is published under “All rights reserved” and discoverable also on: MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital library as a curated and catalogued resource. Core Models: The Secret Code of Vicious and Virtuous Cycles! How Small Actions Create Big Successes or Big Problems https://doi.org/10.5281/zenodo.17671018 This work is published under “All rights reserved” and discoverable also on: MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital library as a curated and catalogued resource. Standardized Core Models of Musculoskeletal Adaptation and Overuse Injury: A Didactic Framework Using the Dr Mihăilă Graphic System® https://doi.org/10.5281/zenodo.20847724 [Anchor Manuscript] This work is published under “All rights reserved” and discoverable also on: MERLOT (Robert Ioan Mihӑilӑ (Member Profile)) digital library as a curated and catalogued resource. The Circular Polar Model of Dr Mihăilă Graphic System®: Axiomatic Architecture, Causal Language, and Construction Methodology │ Illustrated Through Text-Based and Linear Model-Based Applications in Iron – Hepcidin Homeostasis, Erythropoiesis, and Adaptive Immune Response [The Admiral Manuscript of the Series] https://doi.org/10.5281/zenodo.24050857 Buclele Secrete Care Guvernează Lumea – Echilibru și Schimbare │The Secret Loops That Shape the World – Balance and Change, https://doi.org/10.5281/zenodo.23104669
Author: Mihăilă, Robert Ioan
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225581292