Work

Embryonic tenocytes express Olfml2b, a potential direct target of Scleraxis

Year: 2026

Type: article

Abstract: We identified Olfml2b as a candidate downstream target of the tendon transcription factor Scleraxis (Scx).Olfml2b is expressed in mouse embryonic tenocytes, colocalizes with a tendon marker Mkx.Luciferase assay identified a Scxresponsive element approximately 5 kb upstream of Olfml2b transcription start site.To investigate its function, we generated an Olfml2b knockout mouse.Despite its tendon-specific expression, loss of Olfml2b did not affect embryonic tendon formation or the gross morphology of adult tendons.These findings indicate that Olfml2b is a possible Scxregulated tendon gene but is dispensable for tendon development.Further study is required on its physiological role.

Source: microPublication biology

DOI: 10.17912/micropub.biology.002428

Authors: Honoka Inoue, Nanami Ogawa, Rio Nakajima, Kohei Arakawa, Masafumi Inui

Institution: Meiji University

Language: English

Topic: Tendon Structure and Treatment

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7225597775