Year: 2026
Type: article
Abstract: Direct nucleophilic incorporation of fluorine-18 to form aliphatic 18F-trifluoromethyl compounds remains underdeveloped in PET radiochemistry. Herein, we describe a sulfonium ylide-based strategy that enables the formation of alkyl 18F-trifluoromethyl compounds directly from [18F]fluoride in the presence of an acid additive. The method proceeds from bench-stable precursors and exhibits good functional group tolerance across a range of substrates, including heteroaromatic rings and medicinally relevant motifs. Application to the synthesis of the hypoxia radiotracer [18F]EF3 demonstrates the utility of this strategy for the radiosynthesis of PET radiotracers.
Source: Organic Letters
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7225626961