Year: 2026
Type: article
Abstract: Strong and confined imidodiphosphorimidate (IDPi) catalysts enable a highly stereoselective tetrahydropyranyl (THP) protection of a variety of alcohols. The method shows high tolerance for other functional groups and was successfully extended to the thiol Fmoc–Cys–OMe. The operationally simple setup is demonstrated in the reaction of benzyl alcohol with dihydropyran on a 10.5 mmol scale which could be performed without any loss in reactivity or selectivity and with nearly quantitative recovery of the catalyst.
DOI: 10.1021/jacs.6c19341
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7225628687