The Role of Iron During Pregnancy and Its Impact on the Fetus and the Maternal Organism
Year: 2026
Type: article
Abstract: Pregnancy places unusually heavy demands on a woman's iron supply, driven by expanded red-cell production, the build-out of the fetoplacental unit, and the sheer growth of the fetus itself. The body responds to this in two directions at once: gut absorption and mobilisation of stored iron both ramp up adaptively, yet for most women this is not enough — without preventive measures, some degree of iron-deficient state develops in almost everyone by the third trimester simply because reserves cannot keep pace with demand. This paper works through the physiology behind iron handling in pregnancy, how iron actually crosses the placenta, what happens to mother and fetus when iron runs short or, conversely, runs too high, and how iron status is currently monitored and adjusted across the trimesters. A recurring theme is the evidence for a U-shaped risk curve — obstetric and metabolic complications cluster at both ends of the iron spectrum, not just at the low end — which argues for tailoring iron supplementation to the individual rather than dosing everyone the same way.
Institution: Tashkent State Medical University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7225633936