A Multi‐Center Hospital‐Based Case–Control Study of Lymphoid and Myeloid Neoplasms ( AsiaLymph ): Study Design and Initial Findings for Body Mass Index, Education, and Family History
Year: 2026
Type: article
Abstract: ABSTRACT Established risk factors account for a small proportion of lymphoid and myeloid neoplasms; many associations have not been conclusively established, etiologic differences across certain subtypes are poorly understood, and most studies have been conducted in Western populations. Investigations in populations with differing exposure patterns, subtype distributions, and genetic architecture are needed to fully understand hematopoietic tumor etiology. To this end, we conducted a large, multicenter, hospital‐based case–control study of lymphoid and myeloid neoplasms in East Asia (AsiaLymph), including 5671 lymphoid cases, 1879 myeloid cases, and 3858 controls. Participants completed an interview and provided biospecimens. Cases underwent central pathology review and were coded into the World Health Organization classification. Herein, we describe the study methods and report associations for body mass index (BMI), education, and family history. Higher BMI at age 20 but not 40 was associated with lymphoid (per 5 kg/m 2 : OR [95% CI]: 1.18 [1.09–1.27]) and myeloid (1.17 [1.05–1.29]) neoplasms. Greater educational attainment was associated with lymphoid (for college versus < primary education: 1.41 [1.21–1.65]) but not myeloid (1.17 [0.95–1.45]; p ‐heterogeneity < 0.01) neoplasms. There were also positive associations between first‐degree family history of hematologic cancer and lymphoid (1.53 [1.15–2.03]) and myeloid (1.65 [1.11–2.44]) neoplasms. In analyses of major subtypes, these risk factors were not associated with NK/T‐cell lymphoma, suggesting a distinct etiology for this subtype. AsiaLymph is one of the largest molecular epidemiology studies of both lymphoid and myeloid neoplasms with central pathology review and will serve as a valuable resource for etiologic investigations into these malignancies.
Source: International Journal of Cancer
DOI: 10.1002/ijc.70810
Authors: Lauren M. Hurwitz, John K. C. Chan, Tai Hing Lam, Kexin Chen, Yok‐Lam Kwong, Caigang Xu, Brian C. Chiu, Raymond Liang, Yu Chieh Su, Dennis Ip, Wei Hu, Bryan A. Bassig, Mark P. Purdue, Jun Xu, Sarah J. Locke, Sophia S. Wang, H. Dean Hosgood, James R. Cerhan, Susan L. Slager, Sonja I. Berndt, Jonathan N. Hofmann, Jianxin Shi, Kai Yu, Shahinaz M. Gadalla, Lisa J. McReynolds, Bu‐Tian Ji, Calvin Ge, Rena R. Jones, Hongji Dai, Zhangyan Lyu, Lugui Qiu, Wei Liu, Huilai Zhang, Xianhuo Wang, Lindsay M. Morton, Stephen J. Chanock, Martha S. Linet, Melissa C. Friesen, Roel Vermeulen, Nathaniel Rothman, Qing Lan
Institutions: Division of Cancer Epidemiology and Genetics, Queen Elizabeth Hospital, University of Hong Kong, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Queen Mary Hospital, Sichuan University, West China Hospital of Sichuan University, University of Chicago, Hong Kong Sanatorium and Hospital, E-Da Hospital, Inova Health System, Inova Fairfax Hospital, City Of Hope National Medical Center, City of Hope, Beckman Research Institute, Albert Einstein College of Medicine, Mayo Clinic, Utrecht University, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,030
OpenAlex ID: W7225635930