A single cell atlas of several popular anti-aging interventions
Year: 2026
Type: article
Abstract: Several popular anti-aging drugs in current society provide application prospects for anti-aging strategies. However, individual aging is a complex process, manifested in the heterogeneity of cell, organ, and tissue aging, as well as the diversity of aging related signaling pathways. Here, we utilize single-nucleus sequencing technology to systematically evaluate the anti-aging effects of several popular anti-aging drugs (metformin [MET], nicotinamide riboside [NR], dasatinib plus quercetin [D+Q], spermidine [SPD]), and drug combination (MET+NR and MET+SPD) across multiple organs (brain, heart, kidney, and liver). All four drugs are capable of upregulating myocyte enhancer factor 2C (Mef2c) to counteract neuron senescence and dysfunction. The drugs improve cardiac aging phenotypes to varying extents, with D+Q showing the most pronounced effects. This study has systematically analyzed the anti-aging effects and related pathways of various drugs across different organs from multiple perspectives, will contribute to the innovation and advancement of anti-aging drug development.
Source: China National GeneBank DataBase
DOI: 10.26036/cnp0007342
Author: 孙宇哲(Yuzhe SUN)
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225644574
FWCI:
Cites:
Cited by:
Related to: