Note No. 21 from the series "Cosmobiology of Mirny". Memory in the network: position, not mass. Proteomic positions of enzyme-loop carriers according to PaxDb 5.0
Year: 2026
Type: preprint
Abstract: Note No. 20 [5] showed that the SABIO-RK database stores the constants of slow (hysteretic) memory of enzymes under neutral names, without containing a term for the phenomenon itself. This work adds a second dimension: the proteomic position of the loop carriers. Using integrated PaxDb 5.0 datasets (human liver, coverage 81%, n=15,891; rat liver, coverage 36%, n=7,972), it is shown that the loop carriers — DHFR (6.28 ppm, rank 4587) and TYMS (0.78 ppm, rank 8065) — lie in the far tail of the distribution, occupying fractions of a percent of the proteome mass, while their neighbors in the folate cycle, SHMT1 (1368 ppm) and MTHFD1 (1049 ppm), are in the top one percent. The cycle runs at full power, while its slow link is vanishingly rare: a rare carrier with long memory sets the temporal dynamics of the network. Memory in the network is held not by mass but by position.
Author: Borodin, Oleg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225660164
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