Long-term fatigue dimensions in the Multidimensional Fatigue Inventory (MFI) up to five years after radiotherapy and their trajectories in men diagnosed with non-metastatic prostate cancer in the international REQUITE study
Year: 2026
Type: article
Abstract: Background Fatigue is a common, multidimensional symptom in cancer patients. Little is known about fatigue dimensions and their trajectories in prostate cancer (PCa). Methods Using the Multidimensional Fatigue Inventory (MFI), 1097 men treated with radiotherapy for non-metastatic PCa (2014–2016) prospectively reported fatigue up to five years later. Prevalent fatigue was defined as scores ≥75th percentile in men aged ≥60 years in a German general population sample. Pre-radiotherapy patient characteristics were examined for their associations with general fatigue, physical fatigue, mental fatigue, reduced activity, and reduced motivation two years later using logistic regression models. Fatigue trajectories up to two years post-radiotherapy were explored using latent class growth analysis and multinomial regression. Results About 72% (785/1097) of patients reported being fatigued for at least one dimension in the MFI from before the start of radiotherapy up to five years later, with 45% (367/816) being fatigued two years post-radiotherapy. Pre-radiotherapy fatigue level (OR: 4.7–9.0), depression (OR: 2.5), diabetes (OR: 1.8–2.2), hypertension (OR: 1.6–1.8), and BMI (OR: 1.8–2.2) were statistically significant predictors of long-term fatigue two years post-radiotherapy across dimensions. Depression, BMI, and pelvic radiotherapy were associated with experiencing a high fatigue trajectory. Conclusions Early fatigue assessments, in addition to self-reported comorbidities and BMI, showed additional benefits beyond symptom detection by providing prognostic value for poorer long-term fatigue outcomes. Multidimensional fatigue assessments could guide tailored symptom management strategies, targeting specific dimensions to address associated impairments in quality of life and functioning.
Source: British Journal of Cancer
Authors: Philipp Heumann, Juan C. Rosas, Miguel E. Aguado-Barrera, David Azria, Axel Benner, Erik Briers, Renée Bultijnck, Ananya Choudhury, Antonio Gómez-Caamaño, Rudolf Kaaks, Maarten Lambrecht, Tiziana Rancati, Barry S. Rosenstein, Dirk De Ruysscher, Martina E. Schmidt, Susanne Singer, Elena Sperk, Hilary Stobart, Ana Vega, Liv Veldeman, Tim Ward, Adam Webb, Catharine M. West, Jenny Chang-Claude, Christopher J. Talbot, Tim Rattay, REQUITE/REQUITEplus/RADprecise consortia, Piet Ost, Yolande Lievens, Pieter Deseyne, Fréderic Duprez, Marc van Eijkeren, Elhaseen Elhamin, Valérie Fonteyne, Annick Van Greveling, Marcus Mareel, Christel Monten, Wilfried De Neve, Leen Paelinck, Giselle Post, Martijn Swimberghe, Katrien Vandecasteele, Tom Vercauteren, Rita Aerts, Soumia Arredouani, Gilles Defraene, Erik van Limberghen, Stephanie Peeters, Caroline Weltens, Ben Vanneste, Celine Bourgier, Muriel Brengues, Roxana Draghici, Morgan Michalet, Marie-Pierre Farcy-Jacquet, Francoise Bons, Thomas Blaschke, Christian Weiß, Irmgard Helmbold, Anusha Müller, Christian Weißenberger, Petra Stegmaier, Johannes Claßen, Ulrich Giesche, Marie-Luise Sautter-Bihl, Burkhard Neu, Thomas Schnabel, Michael Ehmann, Benjamin Gauter-Fleckenstein, Frank Giordano, Carsten Herskind, Marlon R. Veldwijk, Jörg Schäfer, Barbara Avuzzi, Alessandro Cicchetti, Francesco Pisani, Tommaso Giandini, Marzia Franceschini, Claudia Sangalli, Sara Morlino, Laura Lozza, Maria C. De Santis, Barbara Noris Chiorda, Riccardo Valdagni, Gabriele Pietro, Elena Delmastro, Elisabetta Garibaldi, Manuel Altabas, Alba Delgado, Noelia Docampo, Alexandra Giraldo, Susana Magriña, Xavier Maldonado, Meritxell Mollà, Bibiana Piqué-Leiva, Mónica Ramos, Victoria M. Reyes, Alejandro Seoane, Sara Gutierrez-Enríquez, Ester Aguado Flor, Olivia Fuentes-Rios, Ana Crujeiras González, Belinda Rodríguez-Lage, Juan Fernández-Tajes, Patricia Calvo-Crespo, Monserrat Miranda Currás, Ana Carballo-Castro, Paula Peleteiro-Higuero, Begoña Taboada-Valladares, Irene Fajardo-Paneque, Paloma Sosa-Fajardo, Laura Torrado-Moya, María Aránzazu Tubío-Abuín, Isabel Dominguez-Rios, Ramón Lobato-Busto, Alison M. Dunning, Laura Fachal, Victoria Harrop, Debbie Payne, Manjusha Keni, Hannah Dobbelaere, Kerstie Johnson, Samuel Lavers, Simon Wright, Sridhar Thiagarajan, Luis Aznar-Garcia, Kiran Kancherla, Christopher Kent, Subramaniam Vasanthan, Ion Bioangiu, Kufre Sampson, Ahmed Osman, Donna Appleton, Monika Kaushik, Frances Kenny, Hazem Khout, Jaroslaw Krupa, Kelly V. Lambert, Simon Pilgrim, Sheila Shokuhi, Kalliope Valassiadou, Corinne Faivre-Finn, Karen Foweraker, Abigail Pascoe, Claire P. Esler, Rebecca M. Elliott, Daniel S. Higginson, Sheryl Green, Ava Golchin, Richard Stock, Sarah L. Kerns, Petra Seibold
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
OpenAlex ID: W7225663533