Work

Patella lymphoma: rare presentation of primary bone lymphoma: a case report

Year: 2026

Type: article

Abstract: Introduction and importance: Primary bone lymphoma (PBL) is a rare bone malignancy, accounting for approximately 7% of malignant bone tumors and less than 1% of all malignant lymphomas. Involvement of the patella is exceptionally uncommon, with only a few cases reported in the literature. Case presentation: A 30-year-old male presented with a 5-month history of chronic anterior knee pain and swelling. Radiographs demonstrated an osteolytic lesion of the patella, while magnetic resonance imaging revealed diffuse replacement of the patella by a lytic lesion. Histopathological examination and immunohistochemistry confirmed diffuse large B-cell lymphoma of the germinal center subtype. Positron emission tomography/computed tomography showed isolated patellar involvement without evidence of systemic disease. Clinical discussion: PBL of the patella presents with non-specific symptoms and may mimic common degenerative knee conditions, resulting in delayed diagnosis. Histopathological examination remains essential for diagnosis. Following six cycles of R-CHOP chemotherapy, the patient achieved a complete metabolic response, with significant clinical and radiological improvement. Conclusion: Patellar lymphoma is an extremely rare entity that should be considered in patients with persistent knee pain and osteolytic patellar lesions. Early diagnosis and multidisciplinary management can lead to favorable outcomes.

Source: International Journal of Surgery Case Reports

DOI: 10.1097/rc9.0000000000001154

Authors: Lamia A. Alkhonain, Abdullah Alhamdan, Reem I. Alkhalifah

Institution: Riyadh Armed Forces Hospital

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,090