Programmable White Blood Cells: A Two-Marker Specificity-Logic Design for Engineered T Cells
Year: 2026
Type: preprint
Abstract: Design paper (SIMULATED, NOT MEASURED) specifying a two-marker AND-gate specificity logic for engineered T cells: a priming receptor for one disease marker induces a killing receptor for a second, so firing requires both markers on the same target cell. Occupancy modelling gives a discrimination ratio of 25.0 versus 2.5 for a single-receptor design, with computed dose, expansion, cytokine-risk, persistence, and antigen-escape budgets, failure modes, and quantitative stopping conditions. All numbers are outputs of the accompanying computation script. Nothing is described as built or tested.
Author: Aldred, William Alexander
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225728627
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