The Metallobiology of Neurodegeneration: An Exhaustive Analysis of Aluminum's Role in Alzheimer's Disease Pathogenesis
Year: 2026
Type: preprint
Abstract: This preprint provides an exhaustive analysis of the metallobiology of neurodegeneration, focusing on the heavily debated role of aluminum in the pathogenesis of Alzheimer's disease. The research synthesizes over five decades of neuropathological, biochemical, and epidemiological data to differentiate between aluminum as a primary deterministic cause and as an aggressive pathogenic cofactor. Early whole-animal induction models and bulk tissue analyses are contrasted with modern high-resolution microprobe techniques, including laser microprobe mass analysis and aluminum-specific fluorescence microscopy, which definitively confirm the precise cellular co-localization of aluminum with intracellular neurofibrillary tangles and extracellular senile plaques. The paper systematically details the specific biochemical mechanisms by which aluminum actively disrupts cellular homeostasis. These mechanisms include the rapid acceleration of amyloid-beta aggregation into toxic oligomers, the induction of tau hyperphosphorylation via kinase dysregulation, and the profound epigenetic silencing of neuronal survival genes through targeted chromatin compaction. Furthermore, this work evaluates the critical modulatory effects of dietary silica and the overriding concept of systemic bioavailability, drawing heavily on longitudinal data from large-scale municipal water cohorts and massive occupational exposure events involving respirable aluminum dust. The synthesis concludes that while aluminum is not the sole initiator of the disease, it acts as a potent pathogenic driver in individuals with preexisting physiological or genetic vulnerabilities, directly accelerating the irreversible cycle of oxidative stress, cytoskeletal collapse, and neuronal apoptosis. Keywords: Metallobiology, Neurotoxicology, Aluminum, Tauopathy, Bioavailability
Author: Hallelujah, Paul
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225731256
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