Serum Protein Changes Attributed to Daily Administration of the Aqueous Extract of Azadirachta indica (Neem Leaf) in Wistar Albino Rats
Year: 2026
Type: article
Abstract: This study investigated the effects of daily administration of an aqueous leaf extract of Azadirachta indica on serum protein profiles in Wistar albino rats. Eighty-four rats were randomly assigned to four groups: a control group and three treatment groups receiving 200, 400, and 600 mg/kg body weight of the extract, respectively, for 26 days. Serum levels of total protein, albumin, and globulin were determined using standard biochemical methods. Results revealed dose-dependent alterations in protein parameters. Albumin levels showed a non-significant increase in the treated groups compared with the control, with the highest value observed at 400 mg/kg. Globulin levels exhibited a decreasing trend across treatment groups, although differences were not statistically significant (p > 0.05). However, total protein levels were significantly reduced (p < 0.05) in the extract-treated groups relative to the control, with the lowest value observed at 600 mg/kg. These findings suggest that, while A. indica may enhance albumin synthesis, it may simultaneously reduce overall protein concentration at higher doses, indicating a modulatory effect on protein metabolism. The study highlights the importance of dose consideration in the use of neem extract and underscores the need for further investigation into its long-term physiological implications.
Source: BIONATURE
Institution: Nnamdi Azikiwe University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7225731659
FWCI:
Cites:
Cited by:
Related to: