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Bridging Soviet Unloading-Dietary Therapy (RDT) Clinical Cohorts to Human Circadian-Metabolic Pathways: A Cross-Lingual Systems-Biology Synthesis of the Day 5-7 Acidotic Crisis

Year: 2026

Type: article

Abstract: Cross-lingual translation and systems-biology pathway enrichment of Soviet/Russian Unloading-Dietary Therapy (Разгрузочно-диетическая терапия, RDT) clinical cohorts (Nikolayev, Kokosov, Goryachinsk) mapped to the 2026 Reactome Human Pathway Database, identifying AMPK/SIRT1/PGC-1a-driven transcriptional resetting of the RORA/REV-ERBa (R-HSA-9933387) and BMAL1/CLOCK (R-HSA-9931509) master circadian oscillator as the molecular correlate of the Day 5-7 Acidotic Crisis.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.24119822

Author: Chappell, Corey

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7225732504

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