Skin-Protective and Anti-Photoaging Potential of a Collagen-Based Bioactive Complex in Hs68 Dermal Fibroblasts
Year: 2026
Type: article
Abstract: As we age, combined intrinsic and extrinsic aging processes lead to functional and structural alterations in the skin. Supplementation with nutraceuticals combining collagen peptides and plant-derived bioactive compounds represents a potential strategy to maintain skin health. In the present study, we aimed to investigate the skin-protective effects of collagen-based bioactive complex (CBC), which contains marine-derived bioactive peptides and plant-derived bioactive compounds, such as Amla, lingonberry, and other bioactive ingredients. Assessed via the ABTS radical scavenging assay, CBC exhibited dose-dependent antioxidant activity. In Hs68 cells, CBC significantly increased cell viability and showed a trend toward enhanced wound closure. Furthermore, in a UVB-induced photoaging cell model, CBC significantly reduced MMP-9 levels, suggesting a potential inhibitory effect on extracellular matrix degradation. Taken together, these findings suggest that CBC supports fibroblast viability and wound closure and attenuates UVB-induced responses associated with skin photoaging, supporting its potential as a multi-component bioactive nutraceutical formulation for maintaining skin health.
Author: Jhang Yu-Syuan
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7225741874