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C(sp)-C(sp2) Bond Formation from Triflates via a Copper-Free Sonogashira Cross-Coupling

Year: 2026

Type: article

Abstract: A rapid and copper-free Sonogashira cross-coupling enabling the direct use of aryl triflates as electrophiles is reported. The palladium-catalyzed protocol operates under simple and robust conditions, overcoming common limitations associated with triflate substrates. Broad scope is demonstrated across electron-rich, electron-neutral, moderately electron-deficient, and heteroaryl triflates, as well as diverse aromatic and aliphatic terminal alkynes. Extension to vinyl triflates further highlights the versatility of the method, offering a practical alternative to the use of corresponding aryl and vinyl halides for C(sp)-C(sp2) bond formation.

Source: ACS Omega

DOI: 10.1021/acsomega.6c07460

Authors: Thomas Lemaitre, Marie Cornu, Anne Sophie Voisin-Chiret, Thomas Cailly, Charline Kieffer

Institutions: Normandie Université, Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen Normandie, Inserm, Centre Hospitalier Universitaire de Caen Normandie, Cyceron

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

OpenAlex ID: W7225752050

FWCI:

Cites: 28

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