Structural Characterization of 1-(2-(2,8-bis(Trifluoromethyl)quinolin-4-yl)-2-hydroxyethyl)pyrrolidin-2-one: An Unexpected Cyclization Product
Year: 2026
Type: article
Abstract: 1-(2-(2,8-bis(Trifluoromethyl)quinolin-4-yl)-2-hydroxyethyl)pyrrolidin-2-one has been synthesized through a multi-step pathway starting from commercially available 4-hydroxy-2,8-bis(trifluoromethyl)quinoline. Structural characterization of this original substituted mefloquine derivative was achieved using FT-IR, 1H-NMR, 13C-NMR and single-crystal X-Ray diffraction analysis.
Source: Molbank
DOI: 10.3390/m2256
Institutions: Agents infectieux, résistance et chimiothérapie, Université de Picardie Jules Verne, Centre National de la Recherche Scientifique, Université de Bordeaux, Inserm, Acides nucléiques: Régulations naturelles et artificielles, Institut des Sciences Moléculaires, Laboratoire de l'Intégration du Matériau au Système, Institut Polytechnique de Bordeaux, Institut de Chimie de la Matière Condensée de Bordeaux
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $603
OpenAlex ID: W7225752581