Project Lazarus-Circuit: Master Journal Map - Advanced Synthetic Biology & Protein Engineering Blueprint
Year: 2026
Type: article
Abstract: This document outlines the system architecture and master journal map for Project Lazarus-Circuit, an autologous, closed-loop regenerative and hematological repair system. The framework leverages a humanized Three-Finger Protein (TFP) chimeric foundry integrated with cross-species functional motifs (Axolotl, Spiny Mouse, Zebrafish, and Naked Mole-Rat) to drive scar-free extracellular matrix remodeling, full-thickness dermal reconstruction, and on-demand bone marrow hematopoiesis. The circuit operates via a double-key Boolean logic gate (AND-gate) requiring simultaneous physiological stress and tissue hypoxia for activation. To ensure patient safety, it incorporates a malignancy override logic system (AND-NOT gate) driven by SynNotch surface sensors, intracellular miRNA switches, an Elephant p53 module, and a Naked Mole-Rat INK4 cell-cycle brake to prevent unauthorized clonal expansion or acceleration of hematological malignancies.
Author: Knights, Paul Stephen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7225756370
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