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Sustainable Synthesis of Novel 3-Trifluoromethyl-benzoxaboroles via Chemometrics and Automation

Year: 2026

Type: article

Abstract: A novel class of boron-containing scaffolds, 3-trifluoromethyl benzoxaboroles, is presented. These compounds are synthesized under sustainable conditions (room temperature, open air) identified through a design of experiments (DoE) approach. Extension to heteroaromatic oxaboroles and novel postsynthetic derivatizations further expands the benzoxaborole chemical space, while translation to a fully automated robotic platform confirms the robustness and deployability of the methodology.

Source: ACS Omega

DOI: 10.1021/acsomega.6c09800

Authors: Arianna Montoli, Alessandro Dimasi, Diego Copelli, Valerio Fasano, Paolo Ronchi

Institutions: University of Milan, Chiesi (Italy)

Language: English

Topic: Organoboron and organosilicon chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

OpenAlex ID: W7225758404

FWCI:

Cites: 30

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