Synthesis of 3, 5-arylation of β-anhydroicaritin and their anticancer activity research
Year: 2026
Type: article
Abstract: A facile convenient method has been developed to construct aryl group on C-3 and C-5 positions of β-anhydroicaritin via Suzuki coupling reaction. The synthesised β-anhydroicaritin derivatives have been charactered by 1HNMR,13NMR and HRMS spectrum. Among them, derivatives 4c and 7g exhibited over 50% growth inhibition against HepG2, whereas 4c, 4g, and 7g showed significant activity against MCF-7, with 7g surpassing 70% inhibition.
Source: Figshare
Authors: Lei Li, Zhao Zhao, Xianheng Wang, Changkuo Zhao
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7225758462
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