Subjective cognitive decline as an early marker of cognitive impairment in Parkinson’s disease
Year: 2026
Type: article
Abstract: Cognitive impairment is one of the non-motor symptoms with the greatest impact on patients and caregiver quality of life. Given its onset and significant relevance during the prodromal phase of Parkinson's disease (PD), and its potential role as an at-risk state for cognitive impairment, this study investigated the role of subjective cognitive decline in PD (PD-SCD) as an early prognostic marker of subsequent cognitive impairment to enhance timely detection and prediction. Additionally, it evaluated how mood-related symptoms (depression, anxiety and apathy) influence this relationship. Data from 577 people with Parkinson's disease (PwPD) and 308 control participants from the Parkinson's Precision Medicine Initiative (PPMI) cohort, together with 142 PwPD from the Luxembourg Parkinson's Study cohort, were analyzed over four visits. PD-SCD, with a baseline prevalence of 21.66% in PPMI and 18.31% in the Luxembourg Parkinson's Study, was associated with an at-risk state for cognitive decline over time. Higher levels of mood-related symptoms (apathy, depression, and anxiety) were observed in the PD-SCD group compared with the people with Parkinson's disease presenting normal cognition group (PD-NC) depending on the cohort. In addition, apathy and depression were cross-sectionally associated with higher levels of subjective cognitive complaints (SCC), underscoring their role as a key feature of the PD-SCD clinical profile, without masking the association between PD-SCD and cognitive impairment. Overall, PD-SCD emerged as a relevant at-risk state of cognitive impairment in PD and as a potential dynamic tracker of cognitive impairment trajectories, highlighting its clinical relevance within the continuum of cognitive impairment in PD.
Source: Journal of Neurology
Authors: Gabriel Martinez Tirado, Patricia Martins Conde, Stefano Sapienza, Holger Fröhlich, Claire Pauly, Sonja R. Jónsdóttir, Rejko Krüger, Jochen Klucken, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy de Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hammot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlann, Anne Grünewald, Armin Rauschenberger, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid-Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Jens Schwamborn, Kirsten Roomp, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Valentin Groues, Venkata Satagopam, Iñigo Yoldi Bergua, Gabriel Martinez Tirado, Jochen Ohnmacht, Anne-Marie Hanff, Carlos Vega, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Sibylle Béchet, Jón Gales, Emna Bouhajja, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean-Paul Nicolay, Nadine Jacoby, Isabel Schwaminger, Liyousew Borga, Sijmen van Schagen, Alan Castro Mejia, Francesca Terranova, Messaline Fomo, Francesca Boschi, Niloofar Kheradbin, Isabelle Rolin
Institutions: University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Centre Hospitalier de Luxembourg, University of Bonn, University Hospital Bonn, Fraunhofer Institute for Algorithms and Scientific Computing, Bonn Aachen International Center for Information Technology, Luxembourg Institute of Health, Laboratoire National de Santé
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,790
Awards: G6417920371, G7711840854, G7879305829
OpenAlex ID: W7225760008