Comparison of Intact Cord Milking and Cut Cord Milking Among Neonates ≥28 Weeks Requiring Resuscitation at Birth: Protocol of a Randomized Controlled Trial
Year: 2026
Type: preprint
Abstract: Background Delayed cord clamping (DCC) and umbilical cord milking (UCM) may improve placental transfusion and neonatal hematological outcomes. In neonates requiring resuscitation at birth, intact cord milking (I-UCM) and cut cord milking (C-UCM) may provide alternative approaches to facilitate placental transfusion. Evidence comparing these approaches in neonates requiring resuscitation is limited. Methods This is a single-centre, prospective, two-arm, parallel-group, superiority randomized controlled trial conducted at St John’s Medical College and Hospital, Bengaluru, India. Neonates born at ≥ 28 weeks of gestation who require resuscitation at birth are eligible. Mothers are approached antenatally and written informed consent is obtained before delivery. Eligible participants are randomized in a 1:1 ratio before birth, with stratification by gestational age (< 37 weeks and ≥ 37 weeks). Trial Registration CTRI/2025/01/079614 prospectively registered on 28 January 2025.
Source: Research Square
Institution: St.John's Medical College Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7225769798